Co-administration of Aloe Vera with Piperine and Moringa Oleifera with Curcumin Attenuate Beryllium Induced Blood Biochemical Alterations in Rat

Abastract:: Female albino rats were administered beryllium nitrate at doses of 1mg/kg i.p. once a day for 90 consecutive days followed by combination therapy of Aloe vera (150mg/kg p.o.) with piperine (2.5mg/kg p.o.) and Moringa oleifera root extract (150mg/kg p.o.) with curcumin (5mg/ kg p.o.) once a day for last 15 days to encounter the characteristic blood biochemical alterations. Exposure of beryllium nitrate induced severe alterations in blood biochemical variables. Beryllium nitrate disturbed liver function test as evidenced by induced leakage of AST, ALT in serum whereas activity of SALP was decreased. Exposure of beryllium nitrate disturbed the kidney function test by increased level of urea, uric acid and creatinine. A significant increase in triglyceride, cholesterol and bilirubin was recorded whereas hemoglobin, albumin and blood sugar was decreased as compare to control. Treatment with therapeutic agents maintained the liver and kidney function test and other blood biochemical variables whereas combination therapy of Aloe vera with piperine was found to be most effective in reversal of blood biochemical variables more towards control. By present study, it can be concluded that combination therapy of Aloe vera with piperine is better option in treatment of beryllium toxicity.